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Literature summary extracted from
- Effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in patients with chronic kidney disease (2010), Neth. J. Med., 68, 15-23.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | medicine | enzyme inhibitors are useful in treatment of hypertension and heart failure, as well as for peritoneal dialysis patients, because inhibit the local tissue renin-angiotensin system, which results in less development of peritoneal fibrosis and a longer life for the peritoneal membrane, overview | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | captopril | the ACE inhibitor shows best renoprotective effect in patients with renal disease | Homo sapiens |  |
| 3.4.15.1 | additional information | antiproteinuric and renoprotective effects of ACE inhibitors, ACEi, overview | Homo sapiens | |
| 3.4.15.1 | ramipril | the ACE inhibitor is associated with a major reduction of proteinuria, slower GFR decline and risk of doubling serum creatinine or progression to end-stage renal disease in patients with nondiabetic kidney disease | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | ACE | - |
Homo sapiens |
| 3.4.15.1 | angiotensin-converting enzyme | - |
Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | malfunction | ACE is involved in risk of GFR decrease, doubling of serum creatinine or progression to ESRD in renal disease | Homo sapiens |
| 3.4.15.1 | physiological function | enzyme inhibitors are useful in treatment of hypertension and heart failure, as well as for peritoneal dialysis patients, because inhibit the local tissue renin-angiotensin system, which results in less development of peritoneal fibrosis and a longer life for the peritoneal membrane, overview | Homo sapiens |
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Release 2023.1 (January 2023)
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