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Literature summary extracted from

  • Bae, D.; Camilli, T.C.; Chun, G.; Lal, M.; Wright, K.; OBrien, T.J.; Patierno, S.R.; Ceryak, S.
    Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis (2009), Mutat. Res., 660, 40-46.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.48 Cr(VI) as Na2CrO4, induces clonogenic lethality Homo sapiens
3.1.3.48 sodium orthovanadate a broad-range PTP inhibitor, abrogated Cr(VI)-induced clonogenic lethality Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.48 fibroblast lung Homo sapiens
-
3.1.3.48 LL24 cell
-
 Homo sapiens
-
3.1.3.48 lung
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 protein tyrosine phosphatase
-
 Homo sapiens
3.1.3.48 PTP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.3.48 malfunction PTPs are integral components of key cell survival pathways, and are responsible for their inactivation, while PTP inhibition is are often associated with enhanced cell proliferation, overview. PTP inhibition in the presence of certain types of DNA damage may lead to increased genomic instability, via bypass of cell cycle checkpoints Homo sapiens
3.1.3.48 physiological function PTPs are integral components of key cell survival pathways, and are responsible for their inactivation, while PTP inhibition is are often associated with enhanced cell proliferation, overview Homo sapiens