Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Rinaldi, G.; Morales, M.E.; Alrefaei, Y.N.; Cancela, M.; Castillo, E.; Dalton, J.P.; Tort, J.F.; Brindley, P.J.
    RNA interference targeting leucine aminopeptidase blocks hatching of Schistosoma mansoni eggs (2009), Mol. Biochem. Parasitol., 167, 118-126.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.11.1 SmLAP1 and SmLAP2, cloning of two discrete LAPs genes, DNA and amino acid sequence determination, genome loci structure, phylogenetic tree, overview Schistosoma mansoni

Protein Variants

EC Number Protein Variants Comment Organism
3.4.11.1 additional information RNA interference targeting leucine aminopeptidase blocks hatching of Schistosoma mansoni eggs, overview. Knockdown of eitherSmLAP1 orSmLAP2, or both together, is accompanied by over 80% inhibition of hatching of schistosome eggs Schistosoma mansoni

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.1 Mn2+ activates Schistosoma mansoni

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.1 Schistosoma mansoni P91803 two discrete LAPs genes, SmLAP1 and SmLAP2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.1 egg LAP plays a central role in hatching of the miracidium from the schistosome egg Schistosoma mansoni
-
3.4.11.1 additional information the SmLAP1 andSmLAP2 genes have different expression patterns in diverse stages of the cycle. Whereas both are equally expressed in the blood dwelling stages, schistosomules and adult,SmLAP2 expression is higher in free living larval, miracidia, and in parasitic intra-snail, sporocysts, stages Schistosoma mansoni
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.1 L-leucine-4-methylcoumaryl-7-amide + H2O
-
 Schistosoma mansoni L-leucine + 7-amino-4-methylcoumarine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.1 LAP
-
 Schistosoma mansoni
3.4.11.1 leucine aminopeptidase
-
 Schistosoma mansoni

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.11.1 37
-
 assay at Schistosoma mansoni

General Information

EC Number General Information Comment Organism
3.4.11.1 physiological function LAP plays a central role in hatching of the miracidium from the schistosome egg Schistosoma mansoni