Literature summary extracted from

Johnson, E.M.; Doyle, J.D.; Wetzel, J.D.; McClung, R.P.; Katunuma, N.; Chappell, J.D.; Washington, M.K.; Dermody, T.S.
Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis (2009), J. Virol., 83, 9630-9640.

Application

EC Number	Application	Comment	Organism
3.4.22.1	medicine	pharmacologic modulation of cathepsin activity diminishes reovirus disease severity	Mus musculus

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.4.22.1	additional information	survival rate of Ctsb-/- mice infected with reovirus is enhanced in comparison to that of wild-type mice	Mus musculus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.22.1	lysosome	-	Mus musculus	5764	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.1	Mus musculus	-	C57BL/6J mice	-
3.4.22.1	Mus musculus C57/BL6J	-	C57BL/6J mice	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.22.1	brain	-	Mus musculus	-
3.4.22.1	heart	-	Mus musculus	-
3.4.22.1	intestine	-	Mus musculus	-
3.4.22.1	L-929 cell	-	Mus musculus	-
3.4.22.1	liver	-	Mus musculus	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.22.1	CTSB	-	Mus musculus

General Information

EC Number	General Information	Comment	Organism
3.4.22.1	malfunction	the cathepsin family of endosomal proteases is required for proteolytic processing of several viruses during entry into host cells, cathepsins contribute to reovirus tropism, spread, and disease outcome. Mammalian reoviruses utilize cathepsins B, L, and S for disassembly of the virus outer capsid and activation of the membrane penetration machinery. The survival rate of Ctsb-/- mice infected with reovirus is enhanced in comparison to that of wild-type mice, viremia in wild-type and cathepsin-deficient mice following peroral inoculation, overview	Mus musculus

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Release 2023.1 (January 2023)