EC Number | Cloned (Comment) | Organism |
---|---|---|
3.3.2.10 | gGenotyping for Ephx2-/-, Ephx2+/-, and Ephx2+/+ mice, overview | Mus musculus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.3.2.10 | additional information | Ephx2-/- mice, sEH knockout and its inhibition prevent hyperglycemia in diabetes, but also that sEH knockout enhances islet GSIS through the amplifying pathway and decreases islet cell apoptosis in diabetes. sEH knockout increases Ca2+ response to high glucose and KCl plus diazoxide, and it reduces islet cell apoptosis in streptozotocin-treated mice | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.3.2.10 | trans-4-[4-(3-adamantan-1-ylureido)-cyclohexyloxy]-benzoic acid | i.e. t-AUCB | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.3.2.10 | soluble | - |
Mus musculus | - |
- |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.3.2.10 | Mus musculus | P34914 | C57BL/6J mice | - |
3.3.2.10 | Mus musculus C57/BL6J | P34914 | C57BL/6J mice | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.3.2.10 | heart | - |
Mus musculus | - |
3.3.2.10 | kidney | - |
Mus musculus | - |
3.3.2.10 | liver | - |
Mus musculus | - |
3.3.2.10 | additional information | sEH tissue distribution, no activity in lung, overview | Mus musculus | - |
3.3.2.10 | pancreatic islet | - |
Mus musculus | - |
3.3.2.10 | spleen | - |
Mus musculus | - |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.3.2.10 | malfunction | sEH knockout and its inhibition prevent hyperglycemia in diabetes, and sEH knockoit also enhances islet GSIS through the amplifying pathway and decreases islet cell apoptosis in diabetes, overview | Mus musculus |
3.3.2.10 | physiological function | sEH is an enzyme involved in the metabolism of endogenous inflammatory and antiapoptotic mediators | Mus musculus |