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Literature summary extracted from

  • Ogawa, A.; Suzuki, Y.; Aoyama, T.; Takeuchi, H.
    Dietary alpha-linolenic acid inhibits angiotensin-converting enzyme activity and mRNA expression levels in the aorta of spontaneously hypertensive rats (2009), J. Oleo Sci., 58, 355-360.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.15.1 angiotensin I + H2O Rattus norvegicus
-
 angiotensin II + His-Leu
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Rattus norvegicus P47820 spontaneously hypertensive rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 aorta
-
 Rattus norvegicus
-
3.4.15.1 heart
-
 Rattus norvegicus
-
3.4.15.1 kidney
-
 Rattus norvegicus
-
3.4.15.1 lung
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 angiotensin I + H2O
-
 Rattus norvegicus angiotensin II + His-Leu
-
 ?
3.4.15.1 hippuryl-His-Leu + H2O
-
 Rattus norvegicus hippuric acid + His-Leu
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.15.1 ACE
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.15.1 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.15.1 8.3
-
 assay at Rattus norvegicus

Expression

EC Number Organism Comment Expression
3.4.15.1 Rattus norvegicus alpha-linolenic acid downregulates ACE expression in the aorta of spontaneously hypertensive rats, but not in other organs, via feeding of 10% alpha-linolenic acid-rich flaxseed oil, control is feeding of high oleic safflower oil down