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Literature summary extracted from

  • Serrano, M.A.; Pivatto, M.; Francisco, W.; Danuello, A.; Regasini, L.O.; Lopes, E.M.; Lopes, M.N.; Young, M.C.; Bolzani, V.S.
    Acetylcholinesterase inhibitory pyridine alkaloids of the leaves of Senna multijuga (2010), J. Nat. Prod., 73, 482-484.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 edrophonium 33.7% inhibition at 0.1 mM, competitive inhibition Electrophorus electricus
3.1.1.7 eserine 20.1% inhibition at 0.1 mM Electrophorus electricus
3.1.1.7 additional information descending order of inhibitory potency is tacrine, edrophonium, neostigmine, eserine, pyridostigmine Electrophorus electricus
3.1.1.7 neostigmine 31.1% inhibition at 0.1 mM Electrophorus electricus
3.1.1.7 pyridostigmine 6.1% inhibition at 0.1 mM Electrophorus electricus
3.1.1.7 tacrine i.e. 9-amino-1,2,3,4-tetrahydroacridine hydrochloride, 54.2% inhibition at 0.1 mM, mixed-type inhibition Electrophorus electricus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.7 acetylcholine + H2O Electrophorus electricus
-
 acetate + choline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Electrophorus electricus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.7 commercial preparation
-
 Electrophorus electricus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylcholine + H2O
-
 Electrophorus electricus acetate + choline
-
 ?
3.1.1.7 additional information activity detection using a capillary electrophoresis, EMMA, method, screening method development and optimization of experimental conditions, overview Electrophorus electricus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
 Electrophorus electricus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.7 8
-
 assay at Electrophorus electricus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.7 additional information
-
 additional information inhibition mechanism analysis and kinetics, overview Electrophorus electricus