Literature summary extracted from

Zraika, S.; Aston-Mourney, K.; Marek, P.; Hull, R.L.; Green, P.S.; Udayasankar, J.; Subramanian, S.L.; Raleigh, D.P.; Kahn, S.E.
Neprilysin impedes islet amyloid formation by inhibition of fibril formation rather than peptide degradation (2010), J. Biol. Chem., 285, 18177-18183.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.24.11	DL-[N-(3-mercapto-2-benzylpropanoyl)]glycine	following neprilysin inhibition, islet amyloid deposition and beta-cell apoptosis increase by 54 and 75%, respectively	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.11	Mus musculus	-	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.24.11	neprilypsin	-	Mus musculus

General Information

EC Number	General Information	Comment	Organism
3.4.24.11	malfunction	following overexpression of neprilysin using an adenovirus encoding neprilysin islet amyloid deposition and beta-cell apoptosis both decrease by 79%	Mus musculus
3.4.24.11	physiological function	neprilysin decreases islet amyloid deposition by inhibiting human islet amyloid polypeptide fibril formation, rather than degrading human islet amyloid polypeptide	Mus musculus

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Release 2023.1 (January 2023)