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Literature summary extracted from

  • Ardi, V.C.; Van den Steen, P.E.; Opdenakker, G.; Schweighofer, B.; Deryugina, E.I.; Quigley, J.P.
    Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway (2009), J. Biol. Chem., 284, 25854-25866.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.35 additional information the presence of an intact active site and hemopexin domain are required for full angiogenesis-inducing activity of the MMP-9 enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.35 Tissue inhibitor of metalloproteinase-1
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.35 82000
-
 2 * 82000, active MMP-9, SDS-PAGE Homo sapiens
3.4.24.35 92000
-
 2 * 92000, proMMP-9, SDS-PAGE Homo sapiens
3.4.24.35 200000
-
 the molecular weight of proMMP-9 is about 200000 Da, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.35 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.35 gelatin-Sepharose column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.35 neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.35 Collagen + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.35 Gelatin + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.35 homodimer 2 * 82000, active MMP-9, SDS-PAGE Homo sapiens
3.4.24.35 homodimer 2 * 92000, proMMP-9, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.24.35 matrix metalloproteinase-9
-
 Homo sapiens
3.4.24.35 MMP-9
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.24.35 physiological function MMP-9 catalytically induces angiogenesis via a basic fibroblast growth factor-2/fibroblast growth factor receptor-2 pathway. The enhanced angiogenesis catalyzed by neutrophil MMP-9 evokes also a localized, low threshold level vascular endothelial growth factor/vascular endothelial growth factor receptor-2 pathway, likely functioning in the formation and/or stabilization of blood vessels Homo sapiens