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Literature summary extracted from

  • Ishimoto, K.; Nakamura, H.; Tachibana, K.; Yamasaki, D.; Ota, A.; Hirano, K.; Tanaka, T.; Hamakubo, T.; Sakai, J.; Kodama, T.; Doi, T.
    Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells (2009), J. Biol. Chem., 284, 22195-22205.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.4 LPIN1 reporter plasmid transiently transfected into Hep-G2 cells Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.4 Huh-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 phosphatidic acid + H2O
-
 Homo sapiens 1,2-diacyl-sn-glycerol + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.4 lipin 1
-
 Homo sapiens
3.1.3.4 phosphatidate phosphatase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.1.3.4 Homo sapiens LPIN1 mRNA levels decrease significantly after transfection with LPIN1 siRNA. LPIN1 mRNA levels are reduced to ca. 0.6fold after transfection with SREBP-1 siRNA down
3.1.3.4 Homo sapiens LPIN1 mRNA does not change in cells transfected with SREBP-2 siRNA. Both the sterol regulatory element and the nuclear factor Y-binding site are important in the regulation of LPIN1 transcription additional information
3.1.3.4 Homo sapiens sterol regulatory element-binding protein 1 (SREBP-1) and nuclear factor Y are necessary for the activation of LPIN1 transcription. Induction of the LPIN1 gene by sterol depletion. The region between nucleotides -2428 and -2378 of the LPIN1 promoter contains sequences that mediate the induction of LPIN1 by sterol depletion. LPIN1 mRNA levels are induced 3.3fold in lipoprotein-deficient serum medium relative to those in sterol-containing medium. In statin-containing medium, LPIN1 mRNA increases 7.2fold up

General Information

EC Number General Information Comment Organism
3.1.3.4 physiological function sterol-mediated regulation of lipin 1 gene transcription modulates triglyceride accumulation Homo sapiens