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Literature summary extracted from

  • Shuman, S.
    DNA ligases: progress and prospects (2009), J. Biol. Chem., 284, 17365-17369.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.5.1.2 2-methylthio-ATP potent inhibitor Enterococcus faecalis

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Chlorella virus
-
-
-
6.5.1.2 Enterococcus faecalis Q837V6
-
-
6.5.1.2 Escherichia coli P15042
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
 Chlorella virus AMP + diphosphate + (deoxyribonucleotide)n+m
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
 Enterococcus faecalis AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
 Escherichia coli AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.1 ATP-dependent DNA ligase
-
 Chlorella virus
6.5.1.2 LigA
-
 Enterococcus faecalis
6.5.1.2 LigA
-
 Escherichia coli
6.5.1.2 NAD+-dependent DNA ligase
-
 Enterococcus faecalis
6.5.1.2 NAD+-dependent DNA ligase
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
6.5.1.1 ATP
-
 Chlorella virus
6.5.1.2 NAD+
-
 Enterococcus faecalis
6.5.1.2 NAD+
-
 Escherichia coli

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.5.1.2 0.0005
-
-
 Enterococcus faecalis 2-methylthio-ATP