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Literature summary extracted from

  • Dharmappa, K.K.; Mohamed, R.; Shivaprasad, H.V.; Vishwanath, B.S.
    Genistein, a potent inhibitor of secretory phospholipase A2: a new insight in down regulation of inflammation (2010), Inflammopharmacology, 18, 25-31.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 genistein inhibits sPLA(2) enzymes of inflammatory exudates in a concentration dependent manner. Increasing the Ca2+ concentration from 2.5 to 15 mM and substrate concentration up to 0.000120 mM does not alter the level of inhibition Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 additional information synovial fluid Homo sapiens
-
3.1.1.4 pleural fluid
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 additional information 14C-oleate radio-labelled Escherichia coli membrane used as substrate Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.4 secretory phospholipase A2
-
 Homo sapiens
3.1.1.4 sPLA(2)
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.1.4 physiological function sPLA(2) induces mouse paw oedema Homo sapiens