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Literature summary extracted from
- Subchronic administration of rosmarinic acid, a natural prolyl oligopeptidase inhibitor, enhances cognitive performances (2010), Fitoterapia, 81, 644-8.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.26 | rosmarinic acid | non-competitive inhibitor | Mus musculus |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.26 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.26 | brain | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.26 | Z-Gly-Pro-4-nitroanilide + H2O | assay at pH 7.0, 30°C | Mus musculus | Z-glycyl-L-proline + 4-nitroaniline | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | POP | - |
Mus musculus |
| 3.4.21.26 | prolyl oligopeptidase | - |
Mus musculus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.26 | 30 | - |
assay at | Mus musculus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.26 | 7 | - |
assay at | Mus musculus |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.26 | 0.0637 | - |
- |
Mus musculus | rosmarinic acid | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | physiological function | involved in memory-related function | Mus musculus |
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Release 2023.1 (January 2023)
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