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Literature summary extracted from

  • Russo, L.C.; Goni, C.N.; Castro, L.M.; Asega, A.F.; Camargo, A.C.; Trujillo, C.A.; Ulrich, H.; Glucksman, M.J.; Scavone, C.; Ferro, E.S.
    Interaction with calmodulin is important for the secretion of thimet oligopeptidase following stimulation (2009), FEBS J., 276, 4358-4371.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.15 Calmodulin interaction with calmodulin is important for the secretion of thimet oligopeptidase following stimulation. Overexpression of calmodulin in HEK293 cells is sufficient to greatly increase the A23187-stimulated secretion of EP24.15, which can be inhibited by the calmodulin inhibitor calmidazolium Mus musculus
3.4.24.15 Calmodulin/Ca2+ Ca2+-dependent interaction with calmodulin is important for the secretion of thimet oligopeptidase following stimulation. Overexpression of calmodulin in HEK293 cells is sufficient to greatly increase the A23187-stimulated secretion of EP24.15, which can be inhibited by the calmodulin inhibitor calmidazolium Homo sapiens
3.4.24.15 additional information A23187 stimulates secretion of EP24.15, synergistic effects of forskolin with A23187, inhibited by protein kinase A inhibitor KT5720 Homo sapiens
3.4.24.15 additional information secretion of EP24.15 from AT-t20 cells can be stimulated by A23187 and corticotrophin-releasing hormone and blocked by brefeldin A and nocodazole Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.15 additional information secretion of EP24.15 from AT-t20 cells can be stimulated by A23187 and corticotrophin-releasing hormone and blocked by brefeldin A and nocodazole Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.15 cytosol EP24.15 colocalizes with calmodulin in the cytosol of resting HEK293 cells Homo sapiens 5829
-
3.4.24.15 extracellular the enzyme is secreted Mus musculus
-
-
3.4.24.15 extracellular the enzyme is secreted Homo sapiens
-
-
3.4.24.15 additional information overexpression of calmodulin in HEK293 cells is sufficient to greatly increase the A23187-stimulated secretion of EP24.15, which can be inhibited by the calmodulin inhibitor calmidazolium Homo sapiens
-
-
3.4.24.15 additional information secretion of EP24.15 from AT-t20 cells can be stimulated by A23187 and corticotrophin-releasing hormone and blocked by brefeldin A and nocodazole Mus musculus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.15 Ca2+ Ca2+-dependent interaction with calmodulin is important for the secretion of thimet oligopeptidase following stimulation. Overexpression of calmodulin in HEK293 cells is sufficient to greatly increase the A23187-stimulated secretion of EP24.15, which can be inhibited by the calmodulin inhibitor calmidazolium Homo sapiens
3.4.24.15 Zn2+ required Mus musculus
3.4.24.15 Zn2+ catalytic zinc, the binding site is rather distinct from the calmodulin/Ca2+ binding site Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.15 Homo sapiens
-
-
-
3.4.24.15 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.15 AtT-20 cell a pituitary tumour cell line Mus musculus
-
3.4.24.15 HEK-293 cell EP24.15 colocalizes with calmodulin in the cytosol of resting HEK293 cells Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.4.24.15 EP24.15
-
 Mus musculus
3.4.24.15 EP24.15
-
 Homo sapiens