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Literature summary extracted from

  • Almeida-Amaral, E.E.; Cardoso, V.C.; Francioli, F.G.; Meyer-Fernandes, J.R.
    Leishmania amazonensis: heme stimulates (Na(+)+K(+))ATPase activity via phosphatidylinositol-specific phospholipase C/protein kinase C-like (PI-PLC/PKC) signaling pathways (2010), Exp. Parasitol., 124, 436-441.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.13 heme heme receptor mediates the stimulatory effect of heme on the (Na+ + K+)ATPase activity through a PIPLC/PKC signaling pathway Leishmania amazonensis

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.13 ET-18-OCH3 specific inhibitors of PI-PLC, 0.1 mM abolish stimulatory effect of 0.00005 mM heme in the PI-PLC/protein kinase C pathway Leishmania amazonensis
4.6.1.13 U73122 specific inhibitors of PI-PLC, 0.05 mM abolish stimulatory effect of heme in the PI-PLC/protein kinase C pathway Leishmania amazonensis

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.13 Leishmania amazonensis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.13 promastigote
-
 Leishmania amazonensis
-

Synonyms

EC Number Synonyms Comment Organism
4.6.1.13 phosphatidylinositol-specific phospholipase C
-
 Leishmania amazonensis
4.6.1.13 phosphatidylinositol-specific PLC
-
 Leishmania amazonensis
4.6.1.13 PI-PLC
-
 Leishmania amazonensis

General Information

EC Number General Information Comment Organism
4.6.1.13 physiological function PI-PLC pathway is involved in the stimulatory effect of heme on (Na+ + K+)ATPase via PKC-like activation Leishmania amazonensis