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Literature summary extracted from

  • Schlotter, Y.M.; Riemers, F.M.; Rutten, V.P.; Knol, E.F.; Willemse, T.
    Enzymes involved in the conversion of arachidonic acid to eicosanoids in the skin of atopic dogs (2010), Exp. Dermatol., 19, e317-e319.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O Canis lupus familiaris
-
 leukotriene B4 i.e. LTB4, a potent inflammatory mediator originating from membrane-derived arachidonic acid ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Canis lupus familiaris
-
 healthy and atopic dogs
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.6 skin enzyme expression analysis in healthy and atopic dogs, overview Canis lupus familiaris
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O
-
 Canis lupus familiaris leukotriene B4
-
 ?
3.3.2.6 leukotriene A4 + H2O
-
 Canis lupus familiaris leukotriene B4 i.e. LTB4, a potent inflammatory mediator originating from membrane-derived arachidonic acid ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.6 leukotriene A4 hydrolase
-
 Canis lupus familiaris
3.3.2.6 LTA4H
-
 Canis lupus familiaris

Expression

EC Number Organism Comment Expression
3.3.2.6 Canis lupus familiaris significantly higher mRNA expression of the key enzymes 5-lipoxygenase, 5-LO activating protein, leukotriene A4 hydrolase, and prostaglandin E synthase 1 and their PGE receptors 2 and 3, occur in canine atopic dermatitis, a chronic inflammatory skin disease, overview up

General Information

EC Number General Information Comment Organism
3.3.2.6 metabolism the enzyme takes part in the pathway for the conversion of arachidonic acid to eicosanoids, overview Canis lupus familiaris