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Literature summary extracted from

  • Araki, T.; Langenick, J.; Gamper, M.; Firtel, R.A.; Williams, J.G.
    Evidence that DIF-1 and hyper-osmotic stress activate a Dictyostelium STAT by inhibiting a specific protein tyrosine phosphatase (2008), Development, 135, 1347-1353.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.48 C649S construction of a myc-tagged PTP3DELTAC649S mutant Dictyostelium discoideum
3.1.3.48 additional information overexpression of PTP3 inhibits nuclear accumulation of STATc at the slug stage Dictyostelium discoideum

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.48 Differentiation inducing factor 1 DIF-1, inhibits PTP3 by induction of serine-threonine phosphorylation of PTP3 Dictyostelium discoideum
3.1.3.48 additional information hyperosmotic stress inhibits PTP3. Overexpression of a dominant inhibitor of PTP3 leads to constitutive tyrosine phosphorylation and ectopic nuclear localisation of STATc Dictyostelium discoideum
3.1.3.48 pervanadate
-
 Dictyostelium discoideum
3.1.3.48 sorbitol
-
 Dictyostelium discoideum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.48 additional information Dictyostelium discoideum STATc becomes tyrosine phosphorylated and accumulates in the nucleus when Dictyostelium cells are exposed to the prestalk cell inducer Differentiation inducing factor 1, DIF-1, or are subjected to hyperosmotic stress ?
-
 ?
3.1.3.48 phosphorylated STAT1c + H2O Dictyostelium discoideum mode of STAT activation, whereby serine-threonine phosphorylation of the cognate protein tyrosine phosphatase PTP3 results in the inhibition of its activity, shifting the phosphorylation-dephosphorylation equilibrium in favour of phosphorylation, overview STAT1c + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Dictyostelium discoideum
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.3.48 phosphoprotein serine-threonine phosphorylation inhibits PTP3, is induced by DIF-1 Dictyostelium discoideum

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.48 AX-2 cell
-
 Dictyostelium discoideum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 4-nitrophenyl phosphate + H2O
-
 Dictyostelium discoideum 4-nitrophenol + phosphate
-
 ?
3.1.3.48 additional information STATc becomes tyrosine phosphorylated and accumulates in the nucleus when Dictyostelium cells are exposed to the prestalk cell inducer Differentiation inducing factor 1, DIF-1, or are subjected to hyperosmotic stress Dictyostelium discoideum ?
-
 ?
3.1.3.48 phosphorylated STAT1c + H2O
-
 Dictyostelium discoideum STAT1c + phosphate
-
 ?
3.1.3.48 phosphorylated STAT1c + H2O mode of STAT activation, whereby serine-threonine phosphorylation of the cognate protein tyrosine phosphatase PTP3 results in the inhibition of its activity, shifting the phosphorylation-dephosphorylation equilibrium in favour of phosphorylation, overview Dictyostelium discoideum STAT1c + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 protein tyrosine phosphatase
-
 Dictyostelium discoideum
3.1.3.48 PTP3
-
 Dictyostelium discoideum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.48 8
-
 assay at, substrate 4-nitrophenyl phosphate Dictyostelium discoideum