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Literature summary extracted from
- Calpains, skeletal muscle function and exercise (2010), Clin. Exp. Pharmacol. Physiol., 37, 385-391.
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.22.52 | Ca2+ | dependent on (0.002-0.02 mM). At resting [Ca2+], mu-calpain is present predominantly in its full-length, unautolysed/unactivated forms. Once activated, mu-calpain appears in its autolysed form. Endogenously expressed mu-calpain is activated within a physiological [Ca2+] range in a Ca2+- and time-dependent manner. Autolysed mu-calpain isoforms have a greater Ca2+ sensitivity than the full-length 80000 Da isoform | Homo sapiens |  |
| 3.4.22.52 | Ca2+ | dependent on (0.002-0.02 mM). At resting [Ca2+], mu-calpain is present predominantly in its full-length, unautolysed/unactivated forms. Once activated, mu-calpain appears in its autolysed form. Endogenously expressed mu-calpain is activated within a physiological [Ca2+] range in a Ca2+- and time-dependent manner. Autolysed mu-calpain isoforms have a greater Ca2+ sensitivity than the full-length 80000 Da isoform | Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.22.52 | 80000 | - |
full-length isoform | Homo sapiens |
| 3.4.22.52 | 80000 | - |
full-length isoform | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.52 | alpha-actinin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.22.52 | alpha-actinin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.22.52 | desmin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.22.52 | desmin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.22.52 | fodrin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.22.52 | fodrin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.22.52 | spectrin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.22.52 | spectrin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.22.52 | titin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.22.52 | titin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.22.52 | troponin complex + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.22.52 | troponin complex + H2O | Rattus norvegicus | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.22.52 | Homo sapiens | - |
- |
- |
| 3.4.22.52 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.22.52 | skeletal muscle | in skeletal muscle, mu-calpain is a freely diffusible protein | Homo sapiens | - |
| 3.4.22.52 | skeletal muscle | in skeletal muscle, mu-calpain is a freely diffusible protein | Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.52 | alpha-actinin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.22.52 | alpha-actinin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.22.52 | desmin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.22.52 | desmin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.22.52 | fodrin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.22.52 | fodrin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.22.52 | spectrin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.22.52 | spectrin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.22.52 | titin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.22.52 | titin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.22.52 | troponin complex + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.22.52 | troponin complex + H2O | - |
Rattus norvegicus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.22.52 | mu-calpain | - |
Homo sapiens |
| 3.4.22.52 | mu-calpain | - |
Rattus norvegicus |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 3.4.22.52 | Homo sapiens | mu-calpain is not activated immediately following sprint, endurance or eccentric exercise. mu-Calpain is not activated 24 h after a single bout of eccentric exercise | additional information |
| 3.4.22.52 | Rattus norvegicus | mu-calpain is not activated immediately following sprint, endurance or eccentric exercise. mu-Calpain is not activated 24 h after a single bout of eccentric exercise | additional information |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.22.52 | physiological function | mu-calpain plays a role in membrane repair and a protective role in skeletal muscle | Homo sapiens |
| 3.4.22.52 | physiological function | mu-calpain plays a role in membrane repair and a protective role in skeletal muscle | Rattus norvegicus |
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