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Literature summary extracted from

  • Westergren, V.S.; Wilson, S.J.; Penrose, J.F.; Howarth, P.H.; Sampson, A.P.
    Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis (2009), Clin. Exp. Allergy, 39, 820-828.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O Homo sapiens
-
 leukotriene B4
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Homo sapiens
-
-
-
4.4.1.20 Homo sapiens Q16873
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.6 basophil
-
 Homo sapiens
-
3.3.2.6 eosinophil
-
 Homo sapiens
-
3.3.2.6 epithelium of the nasal airway Homo sapiens
-
3.3.2.6 lamina propria
-
 Homo sapiens
-
3.3.2.6 mast cell
-
 Homo sapiens
-
3.3.2.6 monocyte
-
 Homo sapiens
-
3.3.2.6 additional information immunohistochemical analysis, overview Homo sapiens
-
3.3.2.6 nasal cavity enzyme expression analysis, overview Homo sapiens
-
3.3.2.6 neutrophil
-
 Homo sapiens
-
4.4.1.20 eosinophil co-localization for 5-lipoxygenase activating protein, LTC4 synthase, cyclooxygenase-1 and prostaglandin D2 synthase in nasal biopsies, 10% of LTC4 synthase-positive cells being eosinophils in perennial and seasonal allergic rhinitis biopsies. In the rhinitic biopsies, LTC4 synthase is detectable in 19% of eosinophils Homo sapiens
-
4.4.1.20 macrophage co-localization for 5-lipoxygenase activating protein, LTC4 synthase, cyclooxygenase-1 and prostaglandin D2 synthase in nasal biopsies. 10-43% of LTC4 synthase-positive cells being macrophages in perennial and seasonal allergic rhinitis biopsies. In the rhinitic biopsies, LTC4 synthase is detectable in 6-76% of macrophages Homo sapiens
-
4.4.1.20 mast cell co-localization for 5-lipoxygenase activating protein, LTC4 synthase, cyclooxygenase-1 and prostaglandin D2 synthase in nasal biopsies, 22-26% of LTC4 synthase-positive cells being mast cells in perennial and seasonal allergic rhinitis biopsies. In the rhinitic biopsies, LTC4 synthase is detectable in 10-38% of mast cells, but it does not localize to mast cells in the normal biopsies Homo sapiens
-
4.4.1.20 additional information nasal biopsies Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.6 LT A4 hydrolase
-
 Homo sapiens
3.3.2.6 LTA4 hydrolase
-
 Homo sapiens
4.4.1.20 LTC4 synthase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
4.4.1.20 Homo sapiens expression in mast cells is not apparent in healthy subjects down
4.4.1.20 Homo sapiens significantly elevated immunoexpression of LTC4 synthase observed in perennial allergic rhinitis biopsies up

General Information

EC Number General Information Comment Organism
3.3.2.6 metabolism no difference in LTA4 hydrolase expression in patients with naturally occurring allergic rhinitis compared to controls, suggesting that LTB4 is less important chronically or that LTA4 hydrolase is not the rate-limiting step in its synthesis Homo sapiens
4.4.1.20 physiological function perennial allergic rhinitis biopsies show 3fold more cells immunostaining for LTC4 synthase compared with seasonal allergic rhinitis biopsies but this is not significant compared with normal biopsies, probably because normal biopsies show relatively high variability for LTC4 synthase Homo sapiens