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Literature summary extracted from

  • Ban, K.; Cooper, A.J.; Samuel, S.; Bhatti, A.; Patel, M.; Izumo, S.; Penninger, J.M.; Backx, P.H.; Oudit, G.Y.; Tsushima, R.G.
    Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning (2008), Circ. Res., 103, 643-653.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.137 additional information generation of PI3Kgamma knockout PI3K-/- mice displaying highly reduced activity, poorer functional recovery, and greater tissue injury following ischemic preconditioning compared to wild-type and PI3Kgamma-/+ mutant hearts. Mice expressing a cardiac-specific kinase-deleted PI3Kalpha are resistant to injury induced by 30 min of ischemia followed by 40 min of reperfusion, their to ischemia/reperfusion correlates with the persistent expression of p110gamma and is blocked by the PI3K inhibitor wortmannin, phosphorylation patterns in PI3K signaling in mutant mice, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.137 LY294002
-
 Mus musculus
2.7.1.137 Wortmannin
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol Mus musculus
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 ?
2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol Mus musculus C57BL/6
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 ?
2.7.1.137 additional information Mus musculus PI3K signaling, overview ?
-
 ?
2.7.1.137 additional information Mus musculus C57BL/6 PI3K signaling, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.137 Mus musculus
-
 C57BL/6 mice
-
2.7.1.137 Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.137 heart
-
 Mus musculus
-
2.7.1.137 additional information the phosphatidylinositol 3-kinase, PI3K, family is a family of conserved lipid and protein kinases that are ubiquitously expressed in many cells, including the heart Mus musculus
-
2.7.1.137 myocardium isozyme phosphatidylinositol 3-kinase gamma Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 ?
2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Mus musculus C57BL/6 ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 ?
2.7.1.137 additional information PI3K signaling, overview Mus musculus ?
-
 ?
2.7.1.137 additional information PI3K signaling, overview Mus musculus C57BL/6 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.137 More the phosphatidylinositol 3-kinase, PI3K, family is a family of conserved lipid and protein kinases that are ubiquitously expressed in many cells, including the heart Mus musculus
2.7.1.137 PI3K
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.137 ATP
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.1.137 physiological function PI3K isozymes play selective roles in ischemic preconditioning, a potent cellular protective mechanism whereby brief periods of sublethal ischemia protect the myocardium from prolonged ischemia-induced injury, overview Mus musculus