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Literature summary extracted from

  • Noguchi, H.; Ueda, M.; Hayashi, S.; Kobayashi, N.; Okitsu, T.; Iwanaga, Y.; Nagata, H.; Liu, X.; Kamiya, H.; Levy, M.F.; Matsumoto, S.
    Comparison of trypsin inhibitors in preservation solution for islet isolation (2009), Cell Transplant., 18, 541-547.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.4 pefabloc
-
 Sus scrofa
3.4.21.4 ulinastatin
-
 Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.4 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.4 pancreas
-
 Sus scrofa
-
3.4.21.4 pancreatic acinar cell
-
 Sus scrofa
-
3.4.21.4 pancreatic islet
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.4 N-benzoyl-L-arginine ethyl ester + H2O
-
 Sus scrofa N-benzoyl-L-arginine + ethanol
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.4 25
-
 assay at Sus scrofa

General Information

EC Number General Information Comment Organism
3.4.21.4 malfunction trypsin from pancreatic acinar cells destroys islets. Thus pancreatic slet transplantation which has emerged as an effective therapy and potential cure for type 1 diabetes mellitus, requires inhibition of trypsin activity by ulinastatin or pefabloc, optimization of islet preservation using the two-layer method, TLM, overview Sus scrofa