Literature summary extracted from

Zhang, Y.; Song, H.; Miao, Y.; Wang, R.; Chen, L.
Frequent transcriptional inactivation of Kallikrein 10 gene by CpG island hypermethylation in non-small cell lung cancer (2010), Cancer Sci., 101, 934-940.

Application

EC Number	Application	Comment	Organism
3.4.21.B41	diagnostics	KLK10 methylation can be used as a biomarker for non-small cell lung cancer	Homo sapiens

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.4.21.B41	gene KLK10, determination of frequency and functional significance of KLK10 hypermethylation in non-small cell lung cancer cells, mRNA expression and methylation status of KLK10 in 78 pairs specimens, overview	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.B41	Homo sapiens	Q6ICR6	gene KLK10	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.B41	A-549 cell	lung adenocarcinoma cell line	Homo sapiens	-
3.4.21.B41	lung	-	Homo sapiens	-
3.4.21.B41	non-small cell lung cancer cell	KLK10 is significantly downregulated as compared to non-cancer samples. CpG island hypermethylation of KLK10 is detected in 46.2% of non-small cell lung cancer tissues	Homo sapiens	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.B41	KLK10	-	Homo sapiens

Expression

EC Number	Organism	Comment	Expression
3.4.21.B41	Homo sapiens	frequent transcriptional inactivation of kallikrein 10 gene by CpG island hypermethylation in non-small cell lung cancer, overview. Restoration of KLK10 expression by 5-Aza-dC treatment	down

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Release 2023.1 (January 2023)