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Literature summary extracted from

  • Pothakos, K.; Robinson, J.K.; Gravanis, I.; Marsteller, D.A.; Dewey, S.L.; Tsirka, S.E.
    Decreased serotonin levels associated with behavioral disinhibition in tissue plasminogen activator deficient (tPA-/-) mice (2010), Brain Res., 1326, 135-142.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.21.68 medicine it is used clinically to dissolve Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.68 vesicle
-
 Mus musculus 31982
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.68 plasminogen + H2O Mus musculus
-
 plasmin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.68 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.68 amygdala
-
 Mus musculus
-
3.4.21.68 brain
-
 Mus musculus
-
3.4.21.68 cerebellar Purkinje cell
-
 Mus musculus
-
3.4.21.68 corpus striatum
-
 Mus musculus
-
3.4.21.68 hippocampus
-
 Mus musculus
-
3.4.21.68 prefrontal cortex
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.68 plasminogen + H2O
-
 Mus musculus plasmin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.68 Tissue plasminogen activator
-
 Mus musculus
3.4.21.68 tPA
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.4.21.68 malfunction decreased serotonin levels associated with behavioral disinhibition in tissue plasminogen activator deficient -/- mice, the tPA-/- mice demonstrate an enhanced tendency to actively explore and engage in behaviors involving more exposure in the open field, O-maze and elevated plus maze Mus musculus
3.4.21.68 physiological function serine protease, which converts plasminogen into plasmin, which in turn degrades fibrin and other extracellular matrix components, tPA plays an important role in the processes of learning and memory, demonstrated at the level of behavior and synaptic plasticity, role in neurodegeneration Mus musculus