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Literature summary extracted from

  • Ulisse, S.; Baldini, E.; Mottolese, M.; Sentinelli, S.; Gargiulo, P.; Brancato, V.; Sorrenti, S.; Di Benedetto, A.; De Antoni, E.; DArmiento, M.
    Increased expression of urokinase plasminogen activator and its cognate receptor in human seminomas (2010), BMC Cancer, 10, 151.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.73 plasminogen activator inhibitor-1 PAI-1 Homo sapiens
3.4.21.73 plasminogen activator inhibitor-2 PAI-2 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.73 extracellular the enzyme is secreted by cell culture of the breast cancer cell line MDA-MB-231 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.73 plasminogen + H2O Homo sapiens
-
 plasmin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.73 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.73 MDA-MB-231 cell a breast cancer cell line Homo sapiens
-
3.4.21.73 additional information quantitative and immunuhistochemic analysis of the urokinase plasminogen activator, its cognate receptor uPAR and the uPA inhibitors PAI-1 and PAI-2 in normal human testis and seminomas, overview Homo sapiens
-
3.4.21.73 seminoma cell
-
 Homo sapiens
-
3.4.21.73 testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.73 plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.73 uPA
-
 Homo sapiens
3.4.21.73 Urokinase
-
 Homo sapiens
3.4.21.73 Urokinase plasminogen activator
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.73 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.73 7.4
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.73 malfunction the urokinase plasminogen activating system is implicated in neoplastic progression and high tissue levels of uPAS components correlate with a poor prognosis in different human cancers Homo sapiens