EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.1 | forskolin | - |
Mus musculus | |
4.6.1.1 | SKF-82958 | - |
Mus musculus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
4.6.1.1 | expressed in COS-7 cells | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.1 | carbamazepine | carbamazepine preferentially inhibits forskolin-stimulated isoforms AC5 and AC1 and all D1 agonist-stimulated adenylate cyclases, with isoforms AC5 and AC7 being the most sensitive. When compared to 1 or 3 mM Mg2+, 10 mM Mg2+ reduces lithium-induced AC5 inhibition by 70%. Carbamazepine competes for adenylate cylcase's catechol-estrogen site | Mus musculus | |
4.6.1.1 | lithium | lithium preferentially inhibits isoform AC5, lithium competes with Mg2+, which is essential for adenylate cyclase activity | Mus musculus | |
4.6.1.1 | additional information | valproate does not affect any forskolin- or D1 receptor-stimulated adenylate cyclase | Mus musculus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.1 | Mg2+ | essential for activity | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.6.1.1 | Mus musculus | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.6.1.1 | ATP | - |
Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.6.1.1 | AC1 | isoform | Mus musculus |
4.6.1.1 | AC5 | isoform | Mus musculus |