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Literature summary extracted from

  • Uchimura, H.; Horisaki, T.; Umeda, T.; Noguchi, H.; Usami, Y.; Li, L.; Terada, T.; Nakamura, S.; Shimizu, K.; Takemura, T.; Habe, H.; Furihata, K.; Omori, T.; Yamane, H.; Nojiri, H.
    Alteration of the substrate specificity of the angular dioxygenase carbazole 1,9a-dioxygenase (2008), Biosci. Biotechnol. Biochem., 72, 3237-3248.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.14.12.22 docking simulation of dibenzo-p-dioxin to wild-type CARDO oxygenase Janthinobacterium sp. J3

Protein Variants

EC Number Protein Variants Comment Organism
1.14.12.22 F275A mutation in oxygenase component. Decrease in activity with carbazole, dibenzo-p-dioxin, anthracene, very low activity with fluorene, fluoranthene Janthinobacterium sp. J3
1.14.12.22 F275I mutation in oxygenase component. Decrease in activity with carbazole, very low activtiy with dibenzo-p-dioxin, anthracene, fluorene, fluoranthene Janthinobacterium sp. J3
1.14.12.22 F275L mutation in oxygenase component. Decrease in activity with carbazole, very low activtiy with dibenzo-p-dioxin, anthracene, fluorene, fluoranthene Janthinobacterium sp. J3
1.14.12.22 F275V mutation in oxygenase component. Decrease in activity with carbazole, very low activtiy with dibenzo-p-dioxin, anthracene, fluorene, fluoranthene Janthinobacterium sp. J3
1.14.12.22 F275W mutation in oxygenase component. Decrease in activity with carbazole, wild-type like activity with dibenzo-p-dioxin, anthracene, fluorene, fluoranthene Janthinobacterium sp. J3
1.14.12.22 F329A mutation in oxygenase component. Decrease in activity with carbazole, dibenzo-p-dioxin, anthracene, very low activity with fluorene, fluoranthene Janthinobacterium sp. J3
1.14.12.22 F329I mutation in oxygenase component. Strong decrease in activity with all substrates tested Janthinobacterium sp. J3
1.14.12.22 F329L mutation in oxygenase component. Strong decrease in activity with all substrates tested Janthinobacterium sp. J3
1.14.12.22 F329V mutation in oxygenase component. Strong decrease in activity with all substrates tested Janthinobacterium sp. J3
1.14.12.22 F329W mutation in oxygenase component. Strong decrease in activity with all substrates tested Janthinobacterium sp. J3
1.14.12.22 I262A mutation in oxygenase component. Decrease in activity with carbazole, dibenzo-p-dioxin, anthracene, very low activity with fluorene, fluoranthene Janthinobacterium sp. J3
1.14.12.22 I262L mutation in oxygenase component. Increase in activity with anthracene Janthinobacterium sp. J3
1.14.12.22 I262V mutation in oxygenase component. Decrease in activity with carbazole, dibenzo-p-dioxin, anthracene, very low activity with fluorene, fluoranthene Janthinobacterium sp. J3
1.14.12.22 I262W mutation in oxygenase component. Decrease in activity with carbazole, dibenzo-p-dioxin, anthracene, very low activity with fluorene, fluoranthene Janthinobacterium sp. J3
1.14.12.22 Q282N mutation in oxygenase component. Decrease in activity with carbazole, very low activtiy with dibenzo-p-dioxin, anthracene, fluorene, fluoranthene Janthinobacterium sp. J3
1.14.12.22 Q282S mutation in oxygenase component. Decrease in activity with carbazole, very low activtiy with dibenzo-p-dioxin, anthracene, fluorene, fluoranthene Janthinobacterium sp. J3
1.14.12.22 Q282Y mutation in oxygenase component. Decrease in activity with carbazole, very low activtiy with dibenzo-p-dioxin, anthracene, fluorene, fluoranthene Janthinobacterium sp. J3

Organism

EC Number Organism UniProt Comment Textmining
1.14.12.22 Janthinobacterium sp. J3
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.12.22 anthracene + NAD(P)H + H+ + O2
-
 Janthinobacterium sp. J3 cis-1,2-dihydroxy-1,2-dihydroanthracene + NAD(P)+
-
 ?
1.14.12.22 carbazole + NAD(P)H + H+ + O2
-
 Janthinobacterium sp. J3 2'-aminobiphenyl-2,3-diol + NAD(P)+
-
 ?
1.14.12.22 dibenzo-p-dioxin + NAD(P)H + H+ + O2
-
 Janthinobacterium sp. J3 2,2',3-trihydroxydiphenyl ether + NAD(P)+
-
 ?
1.14.12.22 dibenzothiophene + NAD(P)H + H+ + O2
-
 Janthinobacterium sp. J3 dibenzothiophene-5-oxide + NAD(P)+
-
 ?
1.14.12.22 fluoranthene + NAD(P)H + H+ + O2 poor substrate Janthinobacterium sp. J3 cis-2,3-dihydroxy-2,3-dihydrofluoranthene + NAD(P)+
-
 ?
1.14.12.22 fluorene + NAD(P)H + H+ + O2
-
 Janthinobacterium sp. J3 9-hydroxyfluorene + NAD(P)+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.12.22 NAD(P)H
-
 Janthinobacterium sp. J3