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Literature summary extracted from
- Contact activation of blood-plasma coagulation (2009), Biomaterials, 30, 1857-1869.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.38 | extracellular | - |
Gallus gallus | - |
- |
| 3.4.21.38 | extracellular | - |
Homo sapiens | - |
- |
| 3.4.21.38 | extracellular | - |
Bos taurus | - |
- |
| 3.4.21.38 | extracellular | - |
Equus caballus | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.38 | Bos taurus | - |
- |
- |
| 3.4.21.38 | Equus caballus | - |
- |
- |
| 3.4.21.38 | Gallus gallus | - |
- |
- |
| 3.4.21.38 | Homo sapiens | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.21.38 | proteolytic modification | activation of zymogen FXII,i.e. Hageman factor, to FXIIa by autoactivation | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.38 | blood | - |
Gallus gallus | - |
| 3.4.21.38 | blood | - |
Homo sapiens | - |
| 3.4.21.38 | blood | - |
Bos taurus | - |
| 3.4.21.38 | blood | - |
Equus caballus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.38 | additional information | surface-catalyzed conversion of the blood zymogen factor XII, i.e. FXII or Hageman factor, to the enzyme FXIIa vis autoactivation is not specific for anionic surfaces. Surface activation is moderated by the protein composition of the fluid phase in which FXII autoactivation occurs by what appears to be a protein adsorption-competition effect. Contact activation of plasma coagulation is potentiated by assembly of activation-complex proteins, i.e. FXII, FXI, prekallikrein, and high-molecular-weight kininogen, directly onto activating surfaces (procoagulants) through specific protein/surface interactions, method evaluation, modelling and value of modeling hypotheticals, adsorption and coagulation kinetics, overview | Gallus gallus | ? | - |
? |  |
| 3.4.21.38 | additional information | surface-catalyzed conversion of the blood zymogen factor XII, i.e. FXII or Hageman factor, to the enzyme FXIIa vis autoactivation is not specific for anionic surfaces. Surface activation is moderated by the protein composition of the fluid phase in which FXII autoactivation occurs by what appears to be a protein adsorption-competition effect. Contact activation of plasma coagulation is potentiated by assembly of activation-complex proteins, i.e. FXII, FXI, prekallikrein, and high-molecular-weight kininogen, directly onto activating surfaces (procoagulants) through specific protein/surface interactions, method evaluation, modelling and value of modeling hypotheticals, adsorption and coagulation kinetics, overview | Homo sapiens | ? | - |
? | |
| 3.4.21.38 | additional information | surface-catalyzed conversion of the blood zymogen factor XII, i.e. FXII or Hageman factor, to the enzyme FXIIa vis autoactivation is not specific for anionic surfaces. Surface activation is moderated by the protein composition of the fluid phase in which FXII autoactivation occurs by what appears to be a protein adsorption-competition effect. Contact activation of plasma coagulation is potentiated by assembly of activation-complex proteins, i.e. FXII, FXI, prekallikrein, and high-molecular-weight kininogen, directly onto activating surfaces (procoagulants) through specific protein/surface interactions, method evaluation, modelling and value of modeling hypotheticals, adsorption and coagulation kinetics, overview | Bos taurus | ? | - |
? | |
| 3.4.21.38 | additional information | surface-catalyzed conversion of the blood zymogen factor XII, i.e. FXII or Hageman factor, to the enzyme FXIIa vis autoactivation is not specific for anionic surfaces. Surface activation is moderated by the protein composition of the fluid phase in which FXII autoactivation occurs by what appears to be a protein adsorption-competition effect. Contact activation of plasma coagulation is potentiated by assembly of activation-complex proteins, i.e. FXII, FXI, prekallikrein, and high-molecular-weight kininogen, directly onto activating surfaces (procoagulants) through specific protein/surface interactions, method evaluation, modelling and value of modeling hypotheticals, adsorption and coagulation kinetics, overview | Equus caballus | ? | - |
? | |
| 3.4.21.38 | prekallikrein + H2O | - |
Gallus gallus | kallikrein + kallikrein prepeptide | - |
? | |
| 3.4.21.38 | prekallikrein + H2O | - |
Homo sapiens | kallikrein + kallikrein prepeptide | - |
? | |
| 3.4.21.38 | prekallikrein + H2O | - |
Bos taurus | kallikrein + kallikrein prepeptide | - |
? | |
| 3.4.21.38 | prekallikrein + H2O | - |
Equus caballus | kallikrein + kallikrein prepeptide | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.38 | factor XIIa | - |
Gallus gallus |
| 3.4.21.38 | factor XIIa | - |
Homo sapiens |
| 3.4.21.38 | factor XIIa | - |
Bos taurus |
| 3.4.21.38 | factor XIIa | - |
Equus caballus |
| 3.4.21.38 | FXIIa | - |
Gallus gallus |
| 3.4.21.38 | FXIIa | - |
Homo sapiens |
| 3.4.21.38 | FXIIa | - |
Bos taurus |
| 3.4.21.38 | FXIIa | - |
Equus caballus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.38 | additional information | - |
temperature not specified in the publication | Homo sapiens |
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