EC Number | Cloned (Comment) | Organism |
---|---|---|
2.5.1.31 | expressed in Escherichia coli | Streptococcus pneumoniae |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.31 | (2E,6E)-farnesyl thiodiphosphate | substrate analogue | Streptococcus pneumoniae | |
2.5.1.31 | (4aS,8aS)-4-hydroxy-2-oxo-1,2,4a,5,6,7,8,8a-octahydro[1,6]naphthyridine-3-carboxylic acid (4-piperidin-1-ylphenyl)amide | - |
Streptococcus pneumoniae | |
2.5.1.31 | 5-benzyl-4-hydroxy-5-methyl-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid (4-cyclohexylphenyl)amide | - |
Streptococcus pneumoniae | |
2.5.1.31 | isopentyl thiodiphosphate | substrate analogue | Streptococcus pneumoniae | |
2.5.1.31 | additional information | tetramic acids are selective and potent inhibitors of UPPS | Streptococcus pneumoniae |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.31 | Mg2+ | - |
Streptococcus pneumoniae |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.31 | Streptococcus pneumoniae | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.5.1.31 | - |
Streptococcus pneumoniae |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.31 | (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | - |
Streptococcus pneumoniae | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
2.5.1.31 | N-(4-benzoylphenyl)-4-hydroxy-2-oxo-5-phenethyl-2,5-dihydro-1H-pyrrole-3-carboxamide + isopentenyl diphosphate | Photo-probe | Streptococcus pneumoniae | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.5.1.31 | undecaprenyl pyrophosphate synthase | - |
Streptococcus pneumoniae |
2.5.1.31 | UPPs | - |
Streptococcus pneumoniae |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.5.1.31 | 0.00063 | - |
pH 7.3, temperature not specified in the publication, N-(4-benzoylphenyl)-4-hydroxy-2-oxo-5-phenethyl-2,5-dihydro-1H-pyrrole-3-carboxamide as substrate | Streptococcus pneumoniae | 5-benzyl-4-hydroxy-5-methyl-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid (4-cyclohexylphenyl)amide |