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Literature summary extracted from

  • Kanungo, J.; Zheng, Y.L.; Amin, N.D.; Kaur, S.; Ramchandran, R.; Pant, H.C.
    Specific inhibition of cyclin-dependent kinase 5 activity induces motor neuron development in vivo (2009), Biochem. Biophys. Res. Commun., 386, 263-267.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.22 p35
-
 Danio rerio
2.7.11.22 p39
-
 Danio rerio

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.22 Danio rerio
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.22 embryo
-
 Danio rerio
-

Synonyms

EC Number Synonyms Comment Organism
2.7.11.22 Cdk5
-
 Danio rerio
2.7.11.22 cyclin-dependent kinase 5
-
 Danio rerio

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.22 ATP
-
 Danio rerio
2.7.11.22 cyclin
-
 Danio rerio

General Information

EC Number General Information Comment Organism
2.7.11.22 malfunction cdk5 knockdown results in supernumerary spinal and cranial motor neurons. While a dominant negative, kinase-dead cdk5 promotes the generation of supernumerary motor neurons, over-expression of cdk5 suppresses motor neuron development Danio rerio
2.7.11.22 physiological function cdk5 plays a critical role in spinal and cranial motor neuron development Danio rerio