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Literature summary extracted from

  • Rao, N.L.; Riley, J.P.; Banie, H.; Xue, X.; Sun, B.; Crawford, S.; Lundeen, K.A.; Yu, F.; Karlsson, L.; Fourie, A.M.; Dunford, P.J.
    Leukotriene A4 hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness (2010), Am. J. Respir. Crit. Care Med., 181, 899-907.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.3.2.6 pharmacology inhibition of LTA4H is a potential therapeutic strategy that can modulate key aspects of asthma Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.6 JNJ 26993135 a selective LTA4H inhibitor, leads to reduction of TH2 cytokines and mucin levels, and blocks mast cell production of LTB4 and suppresses airway hyperresponsiveness Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Mus musculus
-
 Balb/c mice
-
3.3.2.6 Mus musculus BALB/c
-
 Balb/c mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.6 lung
-
 Mus musculus
-
3.3.2.6 mast cell bone marrow-derived Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
3.3.2.6 leukotriene A4 hydrolase
-
 Mus musculus
3.3.2.6 LTA4H
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.3.2.6 malfunction enzyme inhibition blocks lung inflammation, antigen uptake by lung dendritic cells and subsequent trafficking of dendritic cells to draining lymph nodes and the lung are decreased upon enzyme inhibition Mus musculus
3.3.2.6 physiological function leukotriene A4 hydrolase is involved in recruitment of both CD4+ and CD8+ T cells to inflammation sites, as well as trafficking of dendritic cells to draining lymph nodes Mus musculus