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Literature summary extracted from

  • Trask, A.J.; Groban, L.; Westwood, B.M.; Varagic, J.; Ganten, D.; Gallagher, P.E.; Chappell, M.C.; Ferrario, C.M.
    Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats (2010), Am. J. Hypertens., 23, 687-693.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.23 MLN-4760
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.17.23 Zn2+
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Rattus norvegicus
-
 wild-type Ren-2 and transgenic hypertensive (mRen2)27 rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.23 cardiomyocyte
-
 Rattus norvegicus
-
3.4.17.23 heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 7-methoxycoumarin-4-acetyl-Ala-Pro-Lys-(2,4-dinitrophenyl)-OH + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.17.23 42
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.17.23 7
-
 assay at Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.4.17.23 malfunction inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats Rattus norvegicus