BRENDA - Enzyme Database show

SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase

Zhang, H.S.; Wu, M.R.; Virus Res. 146, 51-57 (2009)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.11.31
5-aminoimidazole-4-carboxamide ribonucleoside
AICAR, AMPK activator, inhibits Tat-induced HIV-1 transactivation
Homo sapiens
2.7.11.31
resveratrol
reverses Tat-mediated reduction in AMPK activation and downstream acetyl-CoA carboxylase activation, inhibits Tat-induced HIV-1 transactivation
Homo sapiens
Application
EC Number
Application
Commentary
Organism
2.7.11.31
drug development
targeting SIRT1-AMPK pathway may serve as a new target for the development of new anti HIV-1 agents
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.11.31
6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine
compound C, potentiates Tat-induced HIV-1 transactivation
Homo sapiens
2.7.11.31
additional information
a significant reduction in AMPK activation and downstream acetyl-CoA carboxylase activation in response to viral Tat protein treatment. Knockdown of SIRT1 by siRNA potentiates Tat-mediated reduction in AMPK activation and downstream acetyl-CoA carboxylase activation. Knockdown of AMPK by siRNA potentiates Tat-induced HIV-1 transactivation
Homo sapiens
2.7.11.31
nicotinamide
SIRT1 inhibitor, potentiates Tat-mediated reduction in AMPK activation and downstream acetyl-CoA carboxylase activation. Potentiates Tat-induced HIV-1 transactivation
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.11.31
Homo sapiens
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.11.31
ATP + acetyl-CoA carboxylase
-
706902
Homo sapiens
ADP + phosphorylated acetyl-CoA carboxylase
-
-
-
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.11.31
5-aminoimidazole-4-carboxamide ribonucleoside
AICAR, AMPK activator, inhibits Tat-induced HIV-1 transactivation
Homo sapiens
2.7.11.31
resveratrol
reverses Tat-mediated reduction in AMPK activation and downstream acetyl-CoA carboxylase activation, inhibits Tat-induced HIV-1 transactivation
Homo sapiens
Application (protein specific)
EC Number
Application
Commentary
Organism
2.7.11.31
drug development
targeting SIRT1-AMPK pathway may serve as a new target for the development of new anti HIV-1 agents
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.11.31
6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine
compound C, potentiates Tat-induced HIV-1 transactivation
Homo sapiens
2.7.11.31
additional information
a significant reduction in AMPK activation and downstream acetyl-CoA carboxylase activation in response to viral Tat protein treatment. Knockdown of SIRT1 by siRNA potentiates Tat-mediated reduction in AMPK activation and downstream acetyl-CoA carboxylase activation. Knockdown of AMPK by siRNA potentiates Tat-induced HIV-1 transactivation
Homo sapiens
2.7.11.31
nicotinamide
SIRT1 inhibitor, potentiates Tat-mediated reduction in AMPK activation and downstream acetyl-CoA carboxylase activation. Potentiates Tat-induced HIV-1 transactivation
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.11.31
ATP + acetyl-CoA carboxylase
-
706902
Homo sapiens
ADP + phosphorylated acetyl-CoA carboxylase
-
-
-
?