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Literature summary extracted from

  • Lepper, T.W.; Oliveira, E.; Koch, G.D.; Berlese, D.B.; Feksa, L.R.
    Lead inhibits in vitro creatine kinase and pyruvate kinase activity in brain cortex of rats (2009), Toxicol. In Vitro, 24, 1045-1051.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.40 additional information cysteamine or glutathione per se do not modify enzymatic activity, but prevent the toxic effects of lead Rattus norvegicus
2.7.1.40 Pb2+ lead inhibits pyruvate kinase activity in a dose-dependent manner by interaction with its thiol groups Rattus norvegicus
2.7.3.2 additional information cysteamine, glutathione, and sodium acetate does not affect cytosolic and mitochondrial creatine kinase activity Rattus norvegicus
2.7.3.2 Pb2+ lead inhibits in vitro the cytosolic and mitochondrial creatine kinase activity at 0.2 mM and that this inhibition is prevented by addition cysteamine to the assay at 0.1 mM and 0.5 mM final concentration Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.40 cytosol
-
 Rattus norvegicus 5829
-
2.7.3.2 cytosol
-
 Rattus norvegicus 5829
-
2.7.3.2 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.40 Rattus norvegicus
-
-
-
2.7.3.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.40 brain cortex cell line
-
 Rattus norvegicus
-
2.7.3.2 brain cortex
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.40 ADP + phosphoenolpyruvate
-
 Rattus norvegicus ATP + pyruvate
-
 ?
2.7.3.2 ATP + creatine
-
 Rattus norvegicus ADP + creatine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.40 ATP:pyruvate 2-O-phosphotransferase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.40 ADP
-
 Rattus norvegicus
2.7.3.2 ATP
-
 Rattus norvegicus