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Literature summary extracted from

  • Halford, R.W.; Russell, D.W.
    Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimers disease, but does extend lifespan (2009), Proc. Natl. Acad. Sci. USA, 106, 3502-3506.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.25 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.25 brain
-
 Mus musculus
-
1.14.14.25 hippocampus
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.25 cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Mus musculus (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.25 CYP46
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.25 NADPH
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.14.14.25 physiological function amyloid precursor protein expression and amyloid plaque deposition in the cortex and hippocampus of male and female Alzheimer's disease mice between the ages of 3 to 15 months are similar in the presence and absence of cholesterol 24-hydroxylase. Loss of one or both cholesterol 24-hydroxylase alleles increases longevity in Alzheimer’s disease mice. Cholesterol synthetic rates are reduced in animals lacking 24-hydroxylase, and this reduction is specific to cholesterol Mus musculus