EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.149 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.1.149 | DU-145 cell | - |
Homo sapiens | - |
2.4.1.149 | LNCaP cell | - |
Homo sapiens | - |
2.4.1.149 | MCF-7 cell | - |
Homo sapiens | - |
2.4.1.149 | MDA-MB-231 cell | - |
Homo sapiens | - |
2.4.1.149 | MDA-MB-435 cell | - |
Homo sapiens | - |
2.4.1.149 | PC-3 cell | - |
Homo sapiens | - |
2.4.1.149 | PC-3H cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.149 | UDP-N-acetylglucosamine + N-acetyllactosamine | - |
Homo sapiens | UDP + GlcNAcbeta(1-3)Galbeta(1-4)GlcNAc | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.1.149 | beta3-N-acetylglucosaminyltransferase 1 | - |
Homo sapiens |
2.4.1.149 | beta3GnT1 | - |
Homo sapiens |
EC Number | Organism | Comment | Expression |
---|---|---|---|
2.4.1.149 | Homo sapiens | the decrease of laminin-binding glycans and consequent increased cell migration are associated with the decreased expression of beta3-N-acetylglucosaminyltransferase-1 | down |
2.4.1.149 | Homo sapiens | forced expression of beta3GnT1 in aggressive cancer cells restores the laminin-binding glycans and decreased tumor formation | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.4.1.149 | physiological function | beta3GnT1 is required for laminin-binding glycan synthesis through formation of a complex with LARGE, thus regulating the function of LARGE | Homo sapiens |