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Literature summary extracted from

  • Sorriento, D.; Ciccarelli, M.; Santulli, G.; Campanile, A.; Altobelli, G.G.; Cimini, V.; Galasso, G.; Astone, D.; Piscione, F.; Pastore, L.; Trimarco, B.; Iaccarino, G.
    The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha (2008), Proc. Natl. Acad. Sci. USA, 105, 17818-17823.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.16 expressed in BAEC cells and HEK-293 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.16 K215R kinase-dead mutant of GRK5 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.16 ATP + ATP + G protein-coupled receptor Homo sapiens
-
 ADP + phosphorylated G protein-coupled receptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.16 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.16 ATP + ATP + G protein-coupled receptor
-
 Homo sapiens ADP + phosphorylated G protein-coupled receptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.16 G-protein-coupled receptor kinase 5
-
 Homo sapiens
2.7.11.16 GPCR kinase
-
 Homo sapiens
2.7.11.16 GRK5
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.16 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.11.16 physiological function the RH domain of GRK5 interacts with IkappaBalpha and causes inhibition of NFkappaB activity, GRK5 overexpression causes nuclear accumulation of IkappaBalpha leading to the inhibition of NFkappaB transcriptional activity, the GRK5-RH domain inhibits TNFalpha transcription, inhibits endothelial cell migration, and vascular tube formation Homo sapiens