BRENDA - Enzyme Database

A new nuclear function of the Entamoeba histolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activity

Tovy, A.; Siman Tov, R.; Gaentzsch, R.; Helm, M.; Ankri, S.; PLoS Pathog. 6, e1000775 (2010)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.1.1.37
enolase
-
Entamoeba histolytica
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.2.1.11
cytoplasm
-
Entamoeba histolytica
5737
-
4.2.1.11
nucleus
-
Entamoeba histolytica
5634
-
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
4.2.1.11
47000
-
SDS-PAGE
Entamoeba histolytica
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.37
additional information
Entamoeba histolytica
using a yeast two-hybrid screen enolase (EC 4.2.1.11) is identified as a Dnmt2-binding protein, acting as a Dnmt2 inhibitor
?
-
-
-
4.2.1.11
2-phospho-D-glycerate
Entamoeba histolytica
-
phosphoenolpyruvate + H2O
-
-
r
4.2.1.11
additional information
Entamoeba histolytica
enolase acts as a DNA methyltransferase 2 inhibitor. Enolase interacts with Ehmeth, and modulates its activity under conditions of glucose starvation inhibiting the binding of Ehmeth and human DNA methyltransferase 2 to Entamoeba histolytica MRS2 DNA
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.37
Entamoeba histolytica
-
-
-
4.2.1.11
Entamoeba histolytica
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.37
trophozoite
-
Entamoeba histolytica
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.37
additional information
using a yeast two-hybrid screen enolase (EC 4.2.1.11) is identified as a Dnmt2-binding protein, acting as a Dnmt2 inhibitor
706464
Entamoeba histolytica
?
-
-
-
-
4.2.1.11
2-phospho-D-glycerate
-
706464
Entamoeba histolytica
phosphoenolpyruvate + H2O
-
-
-
r
4.2.1.11
additional information
enolase acts as a DNA methyltransferase 2 inhibitor. Enolase interacts with Ehmeth, and modulates its activity under conditions of glucose starvation inhibiting the binding of Ehmeth and human DNA methyltransferase 2 to Entamoeba histolytica MRS2 DNA
706464
Entamoeba histolytica
?
-
-
-
-
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.1.1.37
enolase
-
Entamoeba histolytica
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.2.1.11
cytoplasm
-
Entamoeba histolytica
5737
-
4.2.1.11
nucleus
-
Entamoeba histolytica
5634
-
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
4.2.1.11
47000
-
SDS-PAGE
Entamoeba histolytica
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.37
additional information
Entamoeba histolytica
using a yeast two-hybrid screen enolase (EC 4.2.1.11) is identified as a Dnmt2-binding protein, acting as a Dnmt2 inhibitor
?
-
-
-
4.2.1.11
2-phospho-D-glycerate
Entamoeba histolytica
-
phosphoenolpyruvate + H2O
-
-
r
4.2.1.11
additional information
Entamoeba histolytica
enolase acts as a DNA methyltransferase 2 inhibitor. Enolase interacts with Ehmeth, and modulates its activity under conditions of glucose starvation inhibiting the binding of Ehmeth and human DNA methyltransferase 2 to Entamoeba histolytica MRS2 DNA
?
-
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.37
trophozoite
-
Entamoeba histolytica
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.37
additional information
using a yeast two-hybrid screen enolase (EC 4.2.1.11) is identified as a Dnmt2-binding protein, acting as a Dnmt2 inhibitor
706464
Entamoeba histolytica
?
-
-
-
-
4.2.1.11
2-phospho-D-glycerate
-
706464
Entamoeba histolytica
phosphoenolpyruvate + H2O
-
-
-
r
4.2.1.11
additional information
enolase acts as a DNA methyltransferase 2 inhibitor. Enolase interacts with Ehmeth, and modulates its activity under conditions of glucose starvation inhibiting the binding of Ehmeth and human DNA methyltransferase 2 to Entamoeba histolytica MRS2 DNA
706464
Entamoeba histolytica
?
-
-
-
-