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Literature summary extracted from

  • Tovy, A.; Siman Tov, R.; Gaentzsch, R.; Helm, M.; Ankri, S.
    A new nuclear function of the Entamoeba histolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activity (2010), PLoS Pathog., 6, e1000775.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.37 enolase
-
 Entamoeba histolytica

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.11 cytoplasm
-
 Entamoeba histolytica 5737
-
4.2.1.11 nucleus
-
 Entamoeba histolytica 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.1.11 47000
-
 SDS-PAGE Entamoeba histolytica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.37 additional information Entamoeba histolytica using a yeast two-hybrid screen enolase (EC 4.2.1.11) is identified as a Dnmt2-binding protein, acting as a Dnmt2 inhibitor ?
-
 ?
4.2.1.11 2-phospho-D-glycerate Entamoeba histolytica
-
 phosphoenolpyruvate + H2O
-
 r
4.2.1.11 additional information Entamoeba histolytica enolase acts as a DNA methyltransferase 2 inhibitor. Enolase interacts with Ehmeth, and modulates its activity under conditions of glucose starvation inhibiting the binding of Ehmeth and human DNA methyltransferase 2 to Entamoeba histolytica MRS2 DNA ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.37 Entamoeba histolytica
-
-
-
4.2.1.11 Entamoeba histolytica
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.37 trophozoite
-
 Entamoeba histolytica
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.37 additional information using a yeast two-hybrid screen enolase (EC 4.2.1.11) is identified as a Dnmt2-binding protein, acting as a Dnmt2 inhibitor Entamoeba histolytica ?
-
 ?
4.2.1.11 2-phospho-D-glycerate
-
 Entamoeba histolytica phosphoenolpyruvate + H2O
-
 r
4.2.1.11 additional information enolase acts as a DNA methyltransferase 2 inhibitor. Enolase interacts with Ehmeth, and modulates its activity under conditions of glucose starvation inhibiting the binding of Ehmeth and human DNA methyltransferase 2 to Entamoeba histolytica MRS2 DNA Entamoeba histolytica ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.37 Dnmt2
-
 Entamoeba histolytica
4.2.1.11 alpha-enolase
-
 Entamoeba histolytica
4.2.1.11 enolase
-
 Entamoeba histolytica