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Literature summary extracted from

  • Nguyen, L.N.; Trofa, D.; Nosanchuk, J.D.
    Fatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infection (2009), PLoS ONE, 4, e8421.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.3.1.86 medicine potential treatment of infection of humans with Candida parapsilosis Candida parapsilosis

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.86 additional information FAS2 KO cells, construction of Fas2 disruptants influences virulence, unability to form normal biofilms Candida parapsilosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.85 cerulenin specific inhibitor Candida parapsilosis
2.3.1.86 cerulenin
-
 Candida parapsilosis

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.85 Candida parapsilosis
-
-
-
2.3.1.86 Candida parapsilosis
-
-
-

Synonyms

EC Number Synonyms Comment Organism
2.3.1.85 fatty acid synthase
-
 Candida parapsilosis
2.3.1.86 CpFas2
-
 Candida parapsilosis
2.3.1.86 fas2
-
 Candida parapsilosis
2.3.1.86 fatty acid synthase
-
 Candida parapsilosis

Expression

EC Number Organism Comment Expression
2.3.1.85 Candida parapsilosis oleic acid and Tween 80 downregulate the expression of the fatty acid synthase while myristic acid, stearic acid, and Tween 40 do not down
2.3.1.85 Candida parapsilosis expression of Fas1 and Fas2 is significantly elevated by the presence of glucose up

General Information

EC Number General Information Comment Organism
2.3.1.85 malfunction Fas2 KO strains are unable to form normal biofilms and are more efficiently killed by murine-like macrophages, J774.16, than the wild type, heterozygous and reconstituted strains, Fas2 KO strains are hypersensitive to human serum, and inhibition of Fas2 in wild type Candida parapsilosis by cerulenin significantly decreases fungal growth in human serum Candida parapsilosis
2.3.1.85 physiological function the Fas2 gene is essential for fungal growth in fatty acid-free medium, but dispensable in medium with fatty acids Candida parapsilosis
2.3.1.86 malfunction construction of Fas2 disruptants influences virulence, unability to form normal biofilms Candida parapsilosis
2.3.1.86 physiological function essential for growth in absence of exogenous fatty acids, involved in unsatured fatty acid production Candida parapsilosis