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Literature summary extracted from

  • Olsson, M.E.; Olofsson, L.M.; Lindahl, A.L.; Lundgren, A.; Brodelius, M.; Brodelius, P.E.
    Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L (2009), Phytochemistry, 70, 1123-1128.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.114 Artemisia annua
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4.2.3.24 Artemisia annua
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.114 apical meristem expression of farnesyl diphosphate synthase takes place in apical and sub-apical cells as well as in mesophyl cells while the three enzymes involved in artemisinin biosynthesis, i.e. amorpha-4,11-diene synthase, amorpha-4,11-diene hydroxylase, a cytochrome P450 monooxygenase, and artemisinic aldehyde DELTA11(13) reductase are expressed only in the apical cells Artemisia annua
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4.2.3.24 secretory trichome apical cell Artemisia annua
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.24 (2E,6E)-farnesyl diphosphate
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 Artemisia annua amorpha-4,11-diene + diphosphate
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 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.3.24 amorpha-4,11-diene synthase
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 Artemisia annua

General Information

EC Number General Information Comment Organism
1.14.14.114 physiological function the first committed steps in the conversion of farnesyl diphosphate to artemisinin are conducted by amorpha-4,11-diene synthase, amorpha-4,11-diene hydroxylase, a cytochrome P450 monooxygenase, ie. CYP71AV1, and artemisinic aldehyde DELTA11(13) reductase Artemisia annua