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Literature summary extracted from

  • Hanioka, N.; Hayashi, K.; Shimizudani, T.; Nagaoka, K.; Koeda, A.; Naito, S.; Narimatsu, S.
    Stereoselective glucuronidation of propranolol in human and cynomolgus monkey liver microsomes: role of human hepatic UDP-glucuronosyltransferase isoforms, UGT1A9, UGT2B4 and UGT2B7 (2008), Pharmacology, 82, 293-303.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 expression in insect cell Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 hyodeoxycholic acid
-
 Homo sapiens
2.4.1.17 propofol
-
 Homo sapiens
2.4.1.17 zidovudine
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 0.135
-
 (S)-propanolol isoform UGT1A9, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.16
-
 (R)-propanolol isoform UGT1A9, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.263
-
 (R)-propanolol isoform UGT2B7, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.289
-
 (S)-propanolol isoform UGT2B7, pH 7.4, 37°C Homo sapiens
2.4.1.17 0.515
-
 (S)-propanolol isoform UGT2B4, pH 7.4, 37°C Homo sapiens
2.4.1.17 1.21
-
 (R)-propanolol isoform UGT2B4, pH 7.4, 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 (R)-propanolol + UDP-glucuronate
-
 Homo sapiens UDP + (R)-propanolol O-glucuronide
-
 ?
2.4.1.17 (S)-propanolol + UDP-glucuronate
-
 Homo sapiens UDP + (S)-propanolol O-glucuronide
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.1.17 0.0614
-
 isoform UGT2B4, substrate (S)-propanolol, pH 7.4, 37°C Homo sapiens hyodeoxycholic acid
2.4.1.17 0.086
-
 isoform UGT1A9, substrate (R)-propanolol, pH 7.4, 37°C Homo sapiens propofol
2.4.1.17 0.102
-
 isoform UGT2B4, substrate (R)-propanolol, pH 7.4, 37°C Homo sapiens hyodeoxycholic acid
2.4.1.17 0.16
-
 isoform UGT1A9, substrate (S)-propanolol, pH 7.4, 37°C Homo sapiens propofol
2.4.1.17 2.54
-
 isoform UGT2B7, substrate (R)-propanolol, pH 7.4, 37°C Homo sapiens zidovudine
2.4.1.17 3.59
-
 isoform UGT2B7, substrate (S)-propanolol, pH 7.4, 37°C Homo sapiens zidovudine