Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Diczfalusy, U.; Miura, J.; Roh, H.K.; Mirghani, R.A.; Sayi, J.; Larsson, H.; Bodin, K.G.; Allqvist, A.; Jande, M.; Kim, J.W.; Aklillu, E.; Gustafsson, L.L.; Bertilsson, L.
    4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians (2008), Pharmacogenet. Genomics, 18, 201-208.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.14.1 medicine plasma concentration of 4beta-hydroxycholesterol may be used as an endogenous marker of CYP3A activity. Concentration of 4beta-hydroxycholesterol increases with the number of active CYP3A5 alleles in Koreans, Swedes and Tanzanians Homo sapiens
1.14.14.55 medicine plasma concentration of 4beta-hydroxycholesterol may be used as an endogenous marker of CYP3A activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.1 Homo sapiens P20815
-
-
1.14.14.55 Homo sapiens P08684
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.1 blood
-
 Homo sapiens
-
1.14.14.55 blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.1 quinine + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.55 quinine + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.1 CYP3A5
-
 Homo sapiens
1.14.14.55 CYP3A4
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.1 NADPH
-
 Homo sapiens
1.14.14.55 NADPH
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.14.1 physiological function differences in the activity of both CYP3A4 and CYP3A5 in Koreans, Swedes and Tanzanians. Both 4beta-hydroxycholesterol and quinine/3-hydroxyquinine metabolic ratio show a higher CYP3A activity in women than in men Homo sapiens
1.14.14.55 physiological function differences in the activity of both CYP3A4 and CYP3A5 in Koreans, Swedes and Tanzanians. Both 4beta-hydroxycholesterol and quinine/3-hydroxyquinine metabolic ratio show a higher CYP3A activity in women than in men Homo sapiens