EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA | Micromonospora echinospora | the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins | S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA | - |
? | |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA | Frankia sp. | the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins | S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA | - |
? | |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA | Micromonospora zionensis | the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates guanine1405 in 16S rRNA to 7-methylguanine, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins | S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA | - |
? | |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA | Frankia sp. CcI3 | the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins | S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.179 | Frankia sp. | Q2J7L5 | strain Ccl3 | - |
2.1.1.179 | Frankia sp. CcI3 | Q2J7L5 | strain Ccl3 | - |
2.1.1.179 | Micromonospora echinospora | Q70KC8 | - |
- |
2.1.1.179 | Micromonospora zionensis | Q7M0R2 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA | the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins | Micromonospora echinospora | S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA | - |
? | |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA | the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins | Frankia sp. | S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA | - |
? | |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA | the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates guanine1405 in 16S rRNA to 7-methylguanine, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins | Micromonospora zionensis | S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA | - |
? | |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA | methylation site is experimentally determined as G1405 by MALDI-ToF mass spectrometry | Micromonospora echinospora | S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA | - |
? | |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA | methylation site is experimentally determined as G1405 by MALDI-ToF mass spectrometry | Frankia sp. | S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA | - |
? | |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA | methylation site is experimentally determined as guanine1405 by MALDI-ToF mass spectrometry | Micromonospora zionensis | S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA | - |
? | |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA | the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates G1405 in 16S rRNA to m7G, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins | Frankia sp. CcI3 | S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA | - |
? | |
2.1.1.179 | S-adenosyl-L-methionine + guanine1405 in 16S rRNA | methylation site is experimentally determined as G1405 by MALDI-ToF mass spectrometry | Frankia sp. CcI3 | S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.179 | GrmA | - |
Micromonospora echinospora |
2.1.1.179 | Krm | - |
Frankia sp. |
2.1.1.179 | sgm | - |
Micromonospora zionensis |
2.1.1.179 | sisomicin-gentamicin methylase | - |
Micromonospora zionensis |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.1.1.179 | physiological function | the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates guanine1405 in 16S rRNA to 7-methylguanine, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins | Micromonospora zionensis |