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Literature summary extracted from

  • Min, W.W.; Yuskaitis, C.J.; Yan, Q.; Sikorski, C.; Chen, S.; Jope, R.S.; Bauchwitz, R.P.
    Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential (2009), Neuropharmacology, 56, 463-472.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.11.26 medicine GSK3 is a fundamental and central component of Fragile X syndrome pathology Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.26 AR-A014418 selective ATP-competitive inhibitor of GSK3 Mus musculus
2.7.11.26 lithium
-
 Mus musculus
2.7.11.26 SB-216763 selective ATP-competitive inhibitor of GSK3 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.26 ATP + protein tau Mus musculus
-
 ADP + protein tau phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.26 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.26 phosphoprotein phosphorylation on serine-21 of GSK3alpha and serine-9 of GSK3beta greatly inhibits the activity of GSK3 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.26 brain
-
 Mus musculus
-
2.7.11.26 brain cortex
-
 Mus musculus
-
2.7.11.26 cerebellum
-
 Mus musculus
-
2.7.11.26 hippocampus
-
 Mus musculus
-
2.7.11.26 striatum
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.26 ATP + protein tau
-
 Mus musculus ADP + protein tau phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.26 glycogen synthase kinase-3
-
 Mus musculus
2.7.11.26 GSK3
-
 Mus musculus
2.7.11.26 GSK3alpha isoform Mus musculus
2.7.11.26 GSK3beta isoform Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.26 ATP
-
 Mus musculus