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Literature summary extracted from

  • Bukowski, R.M.; Yasothan, U.; Kirkpatrick, P.
    Pazopanib (2010), Nat. Rev. Drug Discov., 9, 17-18.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.1 pazopanib i.e. 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulphonamide, potent inhibitor of vascular endothelial growth factor receotors 1, 2, and 3, platelet-derived growth factor receptor alpha, platelet-derived growth factor receptor beta, and KIT Homo sapiens
2.7.10.1 sorafenib
-
 Homo sapiens
2.7.10.1 sunitinib
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.1 ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.1 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.1 ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.1 KIT
-
 Homo sapiens
2.7.10.1 PDGFR-alpha isoform Homo sapiens
2.7.10.1 PDGFR-beta isoform Homo sapiens
2.7.10.1 platelet-derived growth factor receptor
-
 Homo sapiens
2.7.10.1 vascular endothelial growth factor
-
 Homo sapiens
2.7.10.1 VEGFR1 isoform Homo sapiens
2.7.10.1 VEGFR2 isoform Homo sapiens
2.7.10.1 VEGFR3 isoform Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.1 ATP
-
 Homo sapiens