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Literature summary extracted from

  • Dovey, M.; Patton, E.E.; Bowman, T.; North, T.; Goessling, W.; Zhou, Y.; Zon, L.I.
    Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish (2009), Mol. Cell. Biol., 29, 3746-3753.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.6.2.2 gene can4, endogenous expression pattern of top2a during development, overview Danio rerio

Protein Variants

EC Number Protein Variants Comment Organism
5.6.2.2 additional information a gene can4 mutant shows impaired embryonal development, phenotype, overview Danio rerio

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.6.2.2 nucleus
-
 Danio rerio 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.2.2 additional information Danio rerio top2a is required for decatenation but not for condensation in embryonic mitoses ?
-
 ?
5.6.2.2 additional information Danio rerio AB top2a is required for decatenation but not for condensation in embryonic mitoses ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.2 Danio rerio
-
 gene can4
-
5.6.2.2 Danio rerio AB
-
 gene can4
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.2.2 embryo endogenous expression pattern of top2a during development, overview Danio rerio
-
5.6.2.2 liver
-
 Danio rerio
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.2 additional information top2a is required for decatenation but not for condensation in embryonic mitoses Danio rerio ?
-
 ?
5.6.2.2 additional information top2a is required for decatenation but not for condensation in embryonic mitoses Danio rerio AB ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.2.2 top2a
-
 Danio rerio
5.6.2.2 topoisomerase II alpha
-
 Danio rerio

General Information

EC Number General Information Comment Organism
5.6.2.2 physiological function topoisomerase II alpha is required for embryonic development and liver regeneration, it is a haploinsufficient regulator of adult liver regrowth, but not of other adult tissues Danio rerio