Literature summary extracted from

Leyton, J.; Smith, G.; Lees, M.; Perumal, M.; Nguyen, Q.D.; Aigbirhio, F.I.; Golovko, O.; He, Q.; Workman, P.; Aboagye, E.O.
Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901 (2008), Mol. Cancer Ther., 7, 3112-3121.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.1.21	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.1.21	SK-MEL-28 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.1.21	ATP + thymidine	-	Homo sapiens	ADP + thymidine 5'-phosphate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.1.21	thymidine kinase I	-	Homo sapiens
2.7.1.21	TK1	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.7.1.21	ATP	-	Homo sapiens

Expression

EC Number	Organism	Comment	Expression
2.7.1.21	Homo sapiens	0.001 mM of the mitogenic extracellular kinase 1/2 inhibitor PD0325901 rapidly decreases thymidine kinase 1 protein levels and mRNA expression in SKMEL-28 human melanoma cells with maximum reduction at 48 h posttreatment	down

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Release 2023.1 (January 2023)