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Literature summary extracted from
- Dipeptidyl peptidase IV in the hypothalamus and hippocampus of monosodium glutamate obese and food-deprived rats (2011), Metab. Clin. Exp., 60, 234-242.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.14.5 | Diprotin A | dipeptidyl peptidase IV in soluble and membrane-bound fractions from the hypothalamus and hippocampus areas is distinguished kinetically as insensitive and sensitive to diprotin A, respectively | Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.14.5 | beta-endorphin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.14.5 | neuropeptide Y + H2O | Rattus norvegicus | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.14.5 | Rattus norvegicus | P14740 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.14.5 | hippocampus | - |
Rattus norvegicus | - |
| 3.4.14.5 | hypothalamus | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.14.5 | beta-endorphin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.14.5 | Gly-L-Pro-4-methoxy-beta-naphthylamide + H2O | - |
Rattus norvegicus | Gly-L-Pro + 4-methoxy-beta-naphthylamine | - |
? | |
| 3.4.14.5 | neuropeptide Y + H2O | - |
Rattus norvegicus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.14.5 | CD26 | - |
Rattus norvegicus |
| 3.4.14.5 | dipeptidyl peptidase IV | - |
Rattus norvegicus |
| 3.4.14.5 | DPPIV | - |
Rattus norvegicus |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 3.4.14.5 | Rattus norvegicus | monosodium glutamate and/or food deprivation decreases the activity of DPPIV insensitive to diprotin A in the soluble and membrane-bound fraction from the hypothalamus, as well as the activity of DPPIV sensitive to diprotin A in the soluble fraction from the hypothalamus and in the membrane-bound fraction from the hippocampus | down |
| 3.4.14.5 | Rattus norvegicus | monosodium glutamate and/or food deprivation increases the activity of DPPIV insensitive to diprotin A in the membrane-bound fraction from the hippocampus | up |
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Release 2023.1 (January 2023)
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