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Literature summary extracted from

  • Gomez, T.A.; Banfield, K.L.; Clarke, S.G.
    The protein L-isoaspartyl-O-methyltransferase functions in the Caenorhabditis elegans stress response (2008), Mech. Ageing Dev., 129, 752-758.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.77
-
 Caenorhabditis elegans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.77 actomyosin
-
 Caenorhabditis elegans 42641
-
2.1.1.77 cytoplasm
-
 Caenorhabditis elegans 5737
-
2.1.1.77 nucleus
-
 Caenorhabditis elegans 5634
-
2.1.1.77 perikaryon
-
 Caenorhabditis elegans 43204
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate Caenorhabditis elegans
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.77 Caenorhabditis elegans
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.77 body wall
-
 Caenorhabditis elegans
-
2.1.1.77 distal tip
-
 Caenorhabditis elegans
-
2.1.1.77 enteric muscle
-
 Caenorhabditis elegans
-
2.1.1.77 gonad
-
 Caenorhabditis elegans
-
2.1.1.77 hypodermis
-
 Caenorhabditis elegans
-
2.1.1.77 neural cord
-
 Caenorhabditis elegans
-
2.1.1.77 neuron
-
 Caenorhabditis elegans
-
2.1.1.77 neuron head region, lateral interneurons and tail region Caenorhabditis elegans
-
2.1.1.77 pharyngeal muscle
-
 Caenorhabditis elegans
-
2.1.1.77 pharynx
-
 Caenorhabditis elegans
-
2.1.1.77 reproductive tissue
-
 Caenorhabditis elegans
-
2.1.1.77 spermathecum
-
 Caenorhabditis elegans
-
2.1.1.77 vulva
-
 Caenorhabditis elegans
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate
-
 Caenorhabditis elegans S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.77 PCM-1
-
 Caenorhabditis elegans
2.1.1.77 protein L-isoaspartyl-O-methyltransferase
-
 Caenorhabditis elegans

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.77 S-adenosyl-L-methionine
-
 Caenorhabditis elegans

Expression

EC Number Organism Comment Expression
2.1.1.77 Caenorhabditis elegans pcm-1 dauer and dauer-like larvae display an average of 46% decrease in lifespan in comparison to N2 dauer and dauer-like larvae down
2.1.1.77 Caenorhabditis elegans upon heat shock and dauer formation-inducing conditions, there is additional pcm-1 expression in body wall muscle nuclei and actomyosin filaments and in hypodermal cells up

General Information

EC Number General Information Comment Organism
2.1.1.77 physiological function worms lacking the pcm-1 gene exhibit reduced longevity as SDS-isolated dauer larvae and as arrested L1 larvae under starvation stress, while overexpression leads to increased adult longevity Caenorhabditis elegans