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Literature summary extracted from
- Breast cancer is associated with an increase in the activity and expression of cholinephosphotransferase in rats (2008), Life Sci., 83, 661-665.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 2.7.8.2 | medicine | cholinephosphotransferase can be used as a biomarker for breast cancer in an animal model | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.8.2 | CDP-choline + 1,2-diacyl-sn-glycerol | Rattus norvegicus | - |
CMP + phosphatidylcholine | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.7.8.2 | Rattus norvegicus | - |
female Sprague Dawley rat | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 2.7.8.2 | breast | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 2.7.8.2 | additional information | - |
0.4 nmol/mg protein, normal breast tissue | Rattus norvegicus |
| 2.7.8.2 | additional information | - |
0.8 nmol/mg protein, dimethylbenz(alpha)anthracene induced tumor | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.8.2 | CDP-choline + 1,2-diacyl-sn-glycerol | - |
Rattus norvegicus | CMP + phosphatidylcholine | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.7.8.2 | cholinephosphotransferase | - |
Rattus norvegicus |
| 2.7.8.2 | CPT | - |
Rattus norvegicus |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 2.7.8.2 | Rattus norvegicus | cholinephosphotransferase activity and its expression are significantly higher in breast cancer tissues | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 2.7.8.2 | physiological function | cholinephosphotransferase is the terminal enzyme for the de novo biosynthesis of phosphatidylcholine | Rattus norvegicus |
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Release 2023.1 (January 2023)
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