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Literature summary extracted from

  • Cannon, N.A.; Donlin, M.J.; Mayes, L.M.; Lyra, A.C.; Di Bisceglie, A.M.; Tavis, J.E.
    Evidence for action of ribavirin through the hepatitis C virus RNA polymerase (2009), J. Viral Hepat., 16, 595-604.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.48 DNA and amino acid sequence determination and analysis, sequence comparisons, NS5B genotyping, enzyme activities, and activity with ribavirin, overview. Expression of His-tagged enzyme variants in Escherichia coli Hepacivirus C

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 Hepacivirus C P26663 i.e. HCV
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.48 recombinant His-tagged enzyme variants from Escherichia coli by nickel affinity chromatography Hepacivirus C

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn
-
 Hepacivirus C diphosphate + RNAn+1
-
 ?
2.7.7.48 ribavirin triphosphate + RNAn ribavirin is a guanosine analogue that can be a substrate for the viral RNA polymerase. HCV is genetically variable, and this genetic variation can affect the polymerase's use of ribavirin triphosphate, overview Hepacivirus C ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.48 NS5B
-
 Hepacivirus C
2.7.7.48 RDRP
-
 Hepacivirus C
2.7.7.48 RNA polymerase
-
 Hepacivirus C